کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11029391 | 1646523 | 2018 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A MAPK/c-Jun-mediated switch regulates the initial adaptive and cell death responses to mitochondrial damage in a neuronal cell model
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کلمات کلیدی
JnkERKAP-1IEGASK1BDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Brain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزactivating protein-1 - فعال کردن پروتئین 1immediate early gene - ژن فوری اولیهextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیapoptosis signal-regulating kinase 1 - کیناز تنظیم کننده سیگنال آپوپتوز 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Parkinson's disease (PD) is defined by the progressive loss of dopaminergic neurons. Mitochondrial dysfunction and oxidative stress are associated with PD although it is not fully understood how neurons respond to these stresses. How adaptive and apoptotic neuronal stress response pathways are regulated and the thresholds at which they are activated remains ambiguous. Utilising SH-SY5Y neuroblastoma cells, we show that MAPK/AP-1 pathways are critical in regulating the response to mitochondrial uncoupling. Here we found the AP-1 transcription factor c-Jun can act in either a pro- or anti-apoptotic manner, depending on the level of stress. JNK-mediated cell death in differentiated cells only occurred once a threshold of stress was surpassed. We also identified a novel feedback loop between Parkin activity and the c-Jun response, suggesting defective mitophagy may initiate MAPK/c-Jun-mediated neuronal loss observed in PD. Our data supports the hypothesis that blocking cell death pathways upstream of c-Jun as a therapeutic target in PD may not be appropriate due to crossover of the pro- and anti-apoptotic responses. Boosting adaptive responses or targeting specific aspects of the neuronal death response may therefore represent more viable therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 104, November 2018, Pages 73-86
Journal: The International Journal of Biochemistry & Cell Biology - Volume 104, November 2018, Pages 73-86
نویسندگان
Thomas A. Ryan, Katherine M. Roper, Jacquelyn Bond, Sandra M. Bell, Sean T. Sweeney, Ewan E. Morrison,