کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11031934 | 1645731 | 2019 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary combination of vitamin E, C and K affects growth, antioxidant activity, and the incidence of systemic granulomatosis in meagre (Argyrosomus regius)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Systemic granulomatosis is a growing disease with a high morbidity, which affects to the majority of farmed meagre (Argyrosomus regius). The impossibility of isolating any infectious agents has hypothesized a nutritional origin of the disease. In order to try to elucidate the nutritional origin of granulomas, juvenile meagre were fed for 15â¯weeks with six diets containing different levels of vitamin E and C and with or without addition of vitamin K: Diet 0 (basal premix, no K, 150â¯mgâ¯kgâ1 E, 20â¯mgâ¯kgâ1C), K (added 23â¯mgâ¯kgâ1â¯K), EC (300â¯mgâ¯kgâ1 E, 70â¯mgâ¯kgâ1C), KEC (23â¯mgâ¯kgâ1â¯K, 300â¯mgâ¯kgâ1 E, 70â¯mgâ¯kgâ1C), EECC (450â¯mgâ¯kgâ1 E, 230â¯mgâ¯kgâ1C) and KEECC (23â¯mgâ¯kgâ1â¯K, 450â¯mgâ¯kgâ1 E, 230â¯mgâ¯kgâ1C). The diet EC significantly increased meagre growth in terms of final weight and length. Fish fed the highest levels of vitamin E and C presented lower percentage of granulomas in liver and heart than fish fed diet 0. The scored severity of granulomatosis in liver and kidney (main affected organs) tended to be lower with dietary increase of vitamin E, C and addition of vitamin K (from 1.83 diet 0 to 1.3 diet KEECC and from 0.91 diet 0 to 0.39 diet KEECC). In liver, the diet KEECC significantly increased catalase expression compared with diet 0. In kidney tnfα expression was significantly up-regulated in fish fed diet EECC and KEECC. In heart, low vitamin E and C levels (300 and 70â¯mgâ¯kgâ1, respectively) significantly increased superoxide dismutase and glutathione peroxidase expression and high addition increased the expression of tnfα and cox-2 (0 or 23â¯mgâ¯kgâ1â¯K, 450â¯mgâ¯kgâ1 E and 230â¯mgâ¯kgâ1C, diet EECC and KEECC). The results show that combination of high dietary content of vitamin K and antioxidant vitamins E and C (23, 450 and 230â¯mgâ¯kgâ1, respectively) influenced in the incidence of the granulomatosis, which suggests that this pathology could be mediated by nutritional factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquaculture - Volume 498, 1 January 2019, Pages 606-620
Journal: Aquaculture - Volume 498, 1 January 2019, Pages 606-620
نویسندگان
Ruiz M.A., Betancor M.B., Robaina L., Montero D., Hernández-Cruz C.M., Izquierdo M.S., Rosenlund G., Fontanillas R., Caballero M.J.,