کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11033936 | 1561006 | 2019 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Understanding facial expressivity in autism spectrum disorder: An inside out review of the biological basis and clinical implications
ترجمه فارسی عنوان
درک اشکال فیزیکی در اختلال طیف اوتیسم: بررسی بیرونی از مبانی بیولوژیکی و پیامدهای بالینی
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کلمات کلیدی
اختلال طیف اوتیسم، شناخت احساسی، ردیابی چشم، مغز اجتماعی، آمیگدالا، گریوس فوزیمور،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Deficits in decoding and understanding facially expressed emotions occur commonly in persons with autism spectrum disorder (ASD), which contribute to the impairment of social communication that serves as one of its core diagnostic criteria. Research suggests that abnormalities of visual scanning of the face, activation of key nodes within the “social brain” by facially expressed emotions, functional connectivity within and between nodes of the “social brain”, and transduction of specific neurotransmitter/neuromodulatory signals contribute to the pathogenesis of these deficits in at least some persons with ASD. Importantly, the etiologies of these deficits are heterogeneous and include genetic, immunologic, and inflammatory mechanisms, as well as in utero exposures to drugs and toxins. The manifestation and severity of these deficits can also be influenced by developmental age, IQ and genetic background. Consistent with the goals of the Special Issue, the current Review is intended to familiarize the readership with several of the leading neurobiological mechanisms proposed to underlie these deficits in decoding facially expressed emotions and stimulate interest in translational preclinical and clinical investigations, whose ultimate purpose is to attenuate their severity and, thereby, improve functional outcomes of persons with ASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 401-417
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 401-417
نویسندگان
Stephen I. Deutsch, C. Teal Raffaele,