کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1163565 1490945 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Field-induced wooden-tip electrospray ionization mass spectrometry for high-throughput analysis of herbal medicines
ترجمه فارسی عنوان
اسپکترومتری جرمی یونیزاسیون الکترو اسپری چوبی ناشی از میدان برای تجزیه و تحلیل بالا از مواد مخدر گیاهی
کلمات کلیدی
تجزیه و تحلیل بالا، یونیزاسیون الکترو اسپری چوبی نوک، طیف سنجی جرمی، ناشی از میدان داروهای گیاهی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• A high-throughput field-induced wooden-tip ESI-MS method was developed.
• An analysis speed of 6 s per sample was achieved.
• The method was applied for high-throughput analysis of herbal medicines.
• Rapidly tracing origin and assessing quality consistency and stability were achieved.
• We provide an effective method for high-throughput analysis of herbal medicines.

This study demonstrates the first application of field-induced wooden-tip electrospray ionization (ESI) mass spectrometry (MS) for high-throughput analysis of herbal medicines. By application of an opposite and sample-contactless high voltage on the MS inlet rather than wooden tips, a high-throughput analysis device is easily set up, and a relatively fast analysis speed of 6 s per sample was successfully achieved. In addition, fast polarity switching between positive and negative ion detection mode is readily accomplished, which provides more complete chemical information for quality assessment and control of herbal medicines. By using the proposed method, various active ingredients present in different herbal medicines were rapidly detected, and the obtained mass spectra were served as the samples' fingerprints for tracing the origins, establishing the authenticity, and assessing the quality consistency and stability of herbal medicines. Our experimental results demonstrated that field-induced wooden-tip ESI-MS is a desirable method for high-throughput analysis of herbal medicines, with promising prospects for rapidly differentiating the origin, determining the authenticity, and assessing the overall quality of pharmaceuticals.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 887, 5 August 2015, Pages 127–137
نویسندگان
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