کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1165645 | 1491074 | 2013 | 7 صفحه PDF | دانلود رایگان |
Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine–glycine–aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to αvβ3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells.
BODIPY polymeric dye bearing cancer-homing cyclic arginine–glycine–aspartic acid peptide residues is used for selective near-infrared imaging of breast cancer cells (MDA-MB-231) through specific cooperative bindings of cancer-homing RGD peptides to αvβ3 integrins of cancer cells.Figure optionsDownload as PowerPoint slideHighlights
► Highly water-soluble near-infrared emissive BODIPY polymeric dye bearing bromide groups (polymer A) was prepared.
► BODIPY polymeric dye bearing RGD peptides (polymer B) was prepared by post-polymerization functionalization.
► Polymer B was used for specific near-infrared fluorescence imaging of breast cancer cells.
Journal: Analytica Chimica Acta - Volume 758, 3 January 2013, Pages 138–144