کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1166551 960502 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of photodynamic therapy (PDT) procedures using microfluidic system
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Evaluation of photodynamic therapy (PDT) procedures using microfluidic system
چکیده انگلیسی

A hybrid PDMS/glass microfluidic system for evaluation of the efficiency of photodynamic therapy is presented. 5-aminolevulinic acid (ALA) was used as a precursor of photosensitizer. The geometry of the microdevice presented in this paper enables to test different concentrations of the photosensitizer in a single assay. The viability of the A549 cells was determined 24 h after PDT procedure (irradiation with light which induced a photosensitizer accumulated in carcinoma cells, λ = 625 nm). The presented results confirmed the possibility to perform the photodynamic therapy process in vitro in microscale and the possibility to assess its effectiveness. Moreover, because two identical microstructures on a single chip were performed, the microchip can be used for examination simultaneously various cell lines (carcinoma and normal) or various photosensitizers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 683, Issue 2, 10 January 2011, Pages 149–155
نویسندگان
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