Flow injection chemiluminescence sensor based on core–shell magnetic molecularly imprinted nanoparticles for determination of sulfadiazine

A novel flow injection chemiluminescence (FI-CL) sensor for determination of sulfadiazine (SDZ) using core–shell magnetic molecularly imprinted polymers (MMIPs) as recognition element is developed. Briefly, a hydrophilic MMIPs layer was produced at the surface of Fe3O4@SiO2 magnetic nanoparticles (MNPs) via combination of molecular imprinting and reversible stimuli responsive hydrogel. And it provided the MMIPs with excellent adsorption capacity and rapid adsorption rate due to the imprinted sites mostly situated on the surface of MMIPs. Then the prepared SDZ-MMIPs were packed into flow cell to establish a novel FI-CL sensor. The sensor provided a wide linear range for SDZ of 4.0 × 10−7 to 1.0 × 10−4 mol L−1 with a detection limit of 1.54 × 10−7 mol L−1. And the relative standard deviation (RSD) for the determination of 1.0 × 10−6 mol L−1 SDZ was 2.56% (n = 11). The proposed method was applied to determine SDZ in urine samples and satisfactory results were obtained.

The preparation of core–shell magnetic molecularly imprinted nanoparticles for determination of sulfadiazine in flow injection chemiluminescence.Figure optionsDownload as PowerPoint slideHighlights
► A sensitive and selectivity sensor for determination of sulfadiazine was developed.
► The magnetic molecularly imprinted polymers exhibited excellent adsorption property.
► The magnetic imprinted products were introduced as chemiluminescence element.
► The sensor displayed high selectivity, low detection limit and long-term stability etc.