کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1167700 1491142 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization of silica surface with nanosize holes for immobilization of biomolecules and analysis of their interactions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Optimization of silica surface with nanosize holes for immobilization of biomolecules and analysis of their interactions
چکیده انگلیسی

An evanescent-field-coupled waveguide-mode sensor of the Kretschmann configuration with a silica waveguide having nanoscale holes is an ideal tool for detection of bimolecular reactions. In the present research, an optimized surface of the sensor with cylindrical nanoscale holes was modified with sodium (1-{[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]oxy}-2,5-dioxopyrrolidine-3-sulfonate) (Sulfo-EMCS) to facilitate the attachment of biomolecules; the resulting surface could be cleaned for reuse simply by changing the pH of the buffering solution. The modification is expected to be useful for wide range of molecular detection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 680, Issues 1–2, 8 November 2010, Pages 72–78
نویسندگان
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