کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1168315 960584 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optical DNA detection based on gold nanorods aggregation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Optical DNA detection based on gold nanorods aggregation
چکیده انگلیسی

Sequence-specific DNA detection is important in various biomedical applications such as gene expression profiling, disease diagnosis and treatment, drug discovery and forensic analysis. Herein, the localized surface plasmon resonance properties of unmodified gold nanorods (GNRs) in 1 mM cetyltrimethyl-ammonium bromide solution were used for sensing DNA sequences, with good simplicity and sensitivity. The intensity of typical plasmon resonance absorption bands of the GNRs decreased with increasing cDNA concentration. The detection of a 30-mer single-stranded oligonucleotide as a model reached a detection limit of about 0.1 pM. This study will be significant for as-prepared GNRs for future application in biological systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 673, Issue 2, 19 July 2010, Pages 179–184
نویسندگان
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