کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1170508 | 960682 | 2006 | 8 صفحه PDF | دانلود رایگان |
A method based on on-line preconcentration followed by liquid chromatography-electrospray ionization–tandem mass spectrometry (LC-ESI–MS/MS) was developed for the determination of three sulfonyl-urea (thifensulfuron, metsulfuron, chlorsulfuron) and two phenyl-urea (isoproturon and chlortoluron) herbicides in water at sub-ppb concentration ranges.Preconcentration was accomplished using on-line enrichment on a C18 cartridge; the procedure was optimized by an evaluation of the breakthrough volumes for the target analytes. Subsequently, LC-ESI–MS/MS was adopted for analytes separation and detection.In particular, a selective reaction monitoring (SRM) approach, based on the detection of a peculiar fragment for each analyte, was chosen for MS/MS analysis, in order to enhance selectivity. Normalization to the response of a phenyl-urea herbicide (chloroxuron), used as an internal standard, was also adopted to achieve a reproducibility enhancement.The described method was applied to the analysis of the target analytes in river water samples and LOD values ranging between 8 and 30 ppt were obtained.
Journal: Analytica Chimica Acta - Volume 575, Issue 1, 4 August 2006, Pages 89–96