کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1171486 | 960721 | 2007 | 5 صفحه PDF | دانلود رایگان |
A simple flow injection chemiluminescence (FI-CL) method was proposed for the determination of nitrofurazone. Strong CL signal was generated during the reaction of nitrofurazone with H2O2 and N-bromosuccinimide (NBS) in alkaline condition. The CL signal was proportional to the nitrofurazone concentration in the range 1.0 × 10−7 to 1.0 × 10−5 g mL−1. The detection limit was 2 × 10−8 g mL−1 nitrofurazone and the relative standard deviation was less than 4% (6.0 × 10−6 g mL−1 nitrofurazone, n = 11). The proposed method was successfully applied to the determination of nitrofurazone in compound furacillin nasal drops, human plasma and urine samples. The CL reaction mechanism was also discussed briefly. Singlet oxygen generated in the reaction between H2O2 and NBS was suggested to be participated in the CL reaction.
Journal: Analytica Chimica Acta - Volume 582, Issue 1, 16 January 2007, Pages 98–102