کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1171798 960732 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A brief review: HPLC methods to directly detect drug glucuronides in biological matrices (Part I)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A brief review: HPLC methods to directly detect drug glucuronides in biological matrices (Part I)
چکیده انگلیسی

Detection of a drug and its glucuronide metabolite(s) is of great importance in interpretive forensic and clinical toxicology. Until recently, glucuronides were determined by cleavage of the glucuronide with an enzyme (e.g., β-glucuronidase) to yield the parent compound, which was subsequently detected, or via derivatization to a more volatile or detectable analogue. Direct detection of the glucuronide conjugates overcomes the critical limitations of approaches that involve enzymatic cleavage procedures and/or derivatization. This review will focus on direct methods to determine glucuronides of various potentially abused drugs in human biological matrices. More specifically, this review will be restricted to methods that involve liquid chromatography (LC) coupled with various detectors. Papers are presented in chronological order for each compound class to emphasize the evolution of methodology and continued importance of the application.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 556, Issue 2, 25 January 2006, Pages 255–266
نویسندگان
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