Effect of calibration standards on the quantification of hydroxy products from can coatings

A liquid chromatographic (LC) method for Bisphenol A diglycidyl ether (BADGE), Bisphenol F diglycidyl ether (BFDGE) and their derivatives is currently being validated at the level of European Committee for Standardisation (CEN). The method consists in hydrolysing the substances to their di-hydroxy forms with a quantification based on calibration using hydrolysed monomers (BADGE·2H2O or BFDGE·2H2O). Considering laboratories may be tempted to use standards of BADGE·2H2O or BFDGE·2H2O now commercially available instead of performing the hydrolysis described, a comparison was made on the effect of using a calibration based on the commercial hydrolysis product versus hydrolysing the monomer on the quantification of the migration limit for enforcement purposes. In this work, the epoxy bis (diol) derivatives were quantified in three different food simulants.