کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1172534 | 1491184 | 2006 | 6 صفحه PDF | دانلود رایگان |

Hydrogen cyanide gas produced during fires can cause poisoning from smoke inhalation. Blood cyanide concentrations in healthy subjects are sub-micromolar. Toxic or fatal blood concentrations are generally considered to be greater than 40 μmol dm−3 but concentrations in survivors can exceed 200 μmol dm−3, while values exceeding 400 μmol dm−3 have been recorded from fatalities.Cyanide in blood is either free in plasma or bound to ferric haemoglobin. Current analytical techniques require sample pre-treatment, generally with extraction of the cyanide from the sample. An amperometric test was developed which could determine free cyanide at physiological pH in a solution of albumin and other blood constituents without sample pre-treatment, with a calibration range exceeding 400 μmol dm−3 and a limit of detection (LOD; using three standard deviations) of 4 μmol dm−3 which is lower than would be treated clinically.
Journal: Analytica Chimica Acta - Volume 558, Issues 1–2, 3 February 2006, Pages 158–163