کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1177789 962610 2015 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The broad diversity of heme-protein cross-links: An overview
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
The broad diversity of heme-protein cross-links: An overview
چکیده انگلیسی


• A broad diversity of heme-protein cross-links have been discovered in the past three decades.
• Heme-protein cross-links are formed under either reductive conditions or oxidative conditions.
• Heme-protein cross-links have distinct effects on protein structure and function.
• Various heme-protein cross-links have been successfully recreated in natural or de novo proteins.
• Heme-protein cross-links may be generally applied to design of artificial heme proteins with advanced functions.

Heme proteins perform a large array of biological functions using the same heme cofactor. A primary method of regulating these diverse functions is the heme-protein cross-link, an important post-translational modification. This review presents an overview of the broad diversity of heme-protein cross-links, including Cys/SeCys -heme, Met-heme, His-heme, Trp/Tyr-heme, Glu/Asp-heme and Lys-heme cross-links, which have been discovered in the last three decades, with bond type ranging from C-S, C-Se, C-N, C-C to C-O. Many advances have been made in revealing the mechanisms of heme-protein cross-link formation, as well as the structural and functional roles. Moreover, most of these cross-links have been successfully recreated in natural or de novo proteins. These tremendous progresses have not only enhanced our knowledge of how cross-links fine-tune the structure and function of natural heme proteins, but also provided us powerful strategies for design of artificial heme proteins with functionalities beyond those of natural heme proteins.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1854, Issue 8, August 2015, Pages 844–859
نویسندگان
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