کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1178258 962678 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reductive elimination of superoxide: Structure and mechanism of superoxide reductases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Reductive elimination of superoxide: Structure and mechanism of superoxide reductases
چکیده انگلیسی

Superoxide anion is among the deleterious reactive oxygen species, towards which all organisms have specialized detoxifying enzymes. For quite a long time, superoxide elimination was thought to occur through its dismutation, catalyzed by Fe, Cu, and Mn or, as more recently discovered, by Ni-containing enzymes. However, during the last decade, a novel type of enzyme was established that eliminates superoxide through its reduction: the superoxide reductases, which are spread among anaerobic and facultative microorganisms, from the three life kingdoms. These enzymes share the same unique catalytic site, an iron ion bound to four histidines and a cysteine that, in its reduced form, reacts with superoxide anion with a diffusion-limited second order rate constant of ∼109 M−1 s−1. In this review, the properties of these enzymes will be thoroughly discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1804, Issue 2, February 2010, Pages 285–297
نویسندگان
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