کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1178474 962694 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The secretome signature of reactive glial cells and its pathological implications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
The secretome signature of reactive glial cells and its pathological implications
چکیده انگلیسی

Glial cells are non-neuronal components of the central nervous system (CNS). They are endowed with diverse functions and are provided with tools to detect their own activities and those of neighboring neurons. Glia and neurons are in continuous reciprocal communication under both physiological and neuropathological conditions, and glia secrete various guidance factors or proteinaceous signals that service vital neuronal–glial interactions in health and disease. Analysis and profiling of glial secretome, especially of microglia and astrocytes, have raised new expectations for the diagnosis and treatment of CNS disorders, and the availability of a catalog of glia-secreted proteins might provide an origin for further research on the complex extracellular signaling mediated by glial cells. Components of the glial secretome play important roles as mediators and modulators of brain structure and function during neuroprotection and neurodegeneration. Therapeutic hypothermia has been acclaimed an effective modulator of brain injury via its substantial effect on the protein expression profiles of glia. Furthermore, emerging proteomic tools and methodologies make feasible the documentation of the reactive glial secretome signature. This review focuses on reactive glial cells and the uniqueness of their secretome during diverse neuropathological conditions. This article is part of a Special Issue entitled: An Updated Secretome.


► The proteomic signatures of glial cells could be utilized to reveal diseased states of CNS.
► Novel biomarkers for the CNS diseases can be developed from glia derived proteins.
► Therapeutic hypothermia has a tremendous impact on the glial proteome and secretome.
► Glial secretome research will undoubtedly contribute to the discovery of new CNS drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1834, Issue 11, November 2013, Pages 2418–2428
نویسندگان
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