کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1179847 1491553 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone contrast optimization in magnetic resonance imaging using experimental design of ultra-short echo-time parameters
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Bone contrast optimization in magnetic resonance imaging using experimental design of ultra-short echo-time parameters
چکیده انگلیسی


• Experimental design was successfully used to explore settings for UTE.
• Optimal UTE settings for bone contrast in MR-imaging were determined.
• Clinically relevant UTE settings for bone contrast in MR-imaging were determined.

For the purpose of improved planning and treatment by radiation of tumours, we present work exploring the effect of controllable ultra-short echo-time (UTE) sequence settings on the bone contrast in magnetic resonance (MR) imaging, using design of experiments (DoE). Images were collected using UTE sequences from MR imaging and from standard computed tomography (CT). CT was used for determining the spatial position of the bony structures in an animal sample and co-registered with the MR images. The effect of the UTE sequence parameter flip angle (Flip), repetition time (TR), echo time (TE), image matrix size (Vox) and number of radial sampling spokes (Samp) were studied. The parameters were also investigated in a healthy voluntary and it was determined that the optimal UTE settings for high bone contrast in a clinically relevant set up were: Flip ~ 9° and TE = 0.07 ms, while TR was kept at 8 ms, Vox at 192 and Samp at 30,000. The use of response surface maps, describing the modelled relation between bone contrast and UTE settings, founded in the DoE, may provide information and be a tool to more appropriately select suitable UTE sequence settings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemometrics and Intelligent Laboratory Systems - Volume 125, 15 June 2013, Pages 33–39
نویسندگان
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