کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1180221 | 1491571 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of three-color cDNA microarray experiments to assess the therapeutic and side effect of drugs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Use of three-color cDNA microarray experiments to assess the therapeutic and side effect of drugs Use of three-color cDNA microarray experiments to assess the therapeutic and side effect of drugs](/preview/png/1180221.png)
چکیده انگلیسی
A novel microarray strategy, three-color cDNA microarray experiment, is originally applied to assess drug effects on gene expression patterns of “target disease.” By adding Alexa 594 as a dye-label for the third target sample, it is made possible to monitor changes in gene expression in response to disease and generate clues to gene function with therapeutic intervention only on one array. A new kind of graph, hexaMplot, is constructed to illustrate the meaningful expression patterns of normal-disease-drug in three-color experiment. The therapeutic and side effect of drugs can be understood and indicated by the different regions of hexaMplot. And the testing of correlation coefficient is explored as a statistical tool of the assessment. Such a methodology may prove useful in shortening the cycle, reducing the cost, and improving the efficiency of drug discovery and development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemometrics and Intelligent Laboratory Systems - Volume 82, Issues 1â2, 26 May 2006, Pages 31-36
Journal: Chemometrics and Intelligent Laboratory Systems - Volume 82, Issues 1â2, 26 May 2006, Pages 31-36
نویسندگان
Hongya Zhao, Ricky N.S. Wong, Kai-Tai Fang, Patrick Y.K. Yue,