Ambient Ionization-Paper Spray Ionization and Its Application

Ambient ionization has gained increasing attentions in recent years due to its characteristics such as simplicity, high efficiency and without sample pretreatment prior to analysis. Although ambient ionization has got a considerable development and has been applied in diverse fields for rapid detection, high-throughput analysis of complex samples has put forward higher requirements to ambient ionization-mass spectrometry. Paper spray ionization source is a recently developed ambient ionization, which has demonstrated promising in high-throughput analysis of foodstuffs and drugs due to its facile operation, low-cost and simple separation in analysis. Herein, the development of paper spray ionization was comprehensively reviewed, and the basic principle, influencing factors, performance of paper spray and its application were highlights. Also, the advantages and disadvantages of this technique were discussed in detail followed by its development directions.

This article reviewed article is focused on the introduction and applications of a simple paper spray ionization source for the rapid detection and quantitation of various targets in complex matrix.Figure optionsDownload as PowerPoint slide