An Electrochemiluminescence Sensor with Molecularly Imprinted Polymer for Heroin Detection

An electrochemiluminescence (ECL) sensor with molecularly imprinted polymer (MIP) film was developed for the detection of heroin. The sensor was prepared by re-modifying the molecularly imprinted polymer film onto Ru(bpy)32+ modified glassy carbon electrode. The electrochemical and electrochemiluminescence behavior of the sensor was investigated. The proposed sensor displayed high sensitivity and excellent selectivity for the target molecule heroin. Under the optimal conditions (a scan rate of 100 mV s−1 and incubation time of 5 min in 0.1 M PBS), a linear response for heroin was achieved in the range of 1.0 × 10−14–1.0 × 10−10 M with a detection limit of 4.0 × 10−15 M (S/N = 3). The sensor was successfully applied for the determination of heroin in urine and saliva with the recovery rates in the range of 97%–104%.

A highly sensitive and selective sensor for heroin determination was developed by the incorporation of a molecularly imprinted polymer with electrochemiluminescence detection. The sensor was successfully applied for the determination of heroin in urine and saliva with satisfactoryrecovery rates.Figure optionsDownload as PowerPoint slide