کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1183489 | 963248 | 2016 | 7 صفحه PDF | دانلود رایگان |
• The maximum oil load in DC grade EEO powder was established at 25–30% (w/w).
• The maximum oil load in DC grade TGO powder was established at 30–35% (w/w).
• X-ray diffractograms of EEO/TGO powders and tablets indicated partial crystallinity.
• NMR showed evidence of true inclusion of EE in β-cyclodextrin.
• Compactibility of commercial omega-3 powders confirmed uniqueness of results.
Omega-3 nutraceuticals are extensively used as health supplements worldwide. Various administration forms for delivery of omega-3 are available. However, the niche omega-3 tablets have so far remained unexplored. In this work tablets containing 25–40% (w/w) omega-3 oil as triglycerides or ethyl esters were prepared utilizing a direct compaction grade powder with β-cyclodextrin as encapsulating agent. It was found that powders with up to 35% (w/w) triglyceride oil and 30% (w/w) ethyl ester oil, respectively, can be directly compressed into tablets of excellent quality. Physical properties of omega-3 containing powders and tablets are described. The powder X-ray diffractograms of the powders and crushed tablets show evidence of the formation of new crystalline phases not present in β-cyclodextrin. In addition, 1H NMR data suggest that the ethyl esters form inclusion complexes with β-cyclodextrin. Compaction of other, commercially available, omega-3 powders was performed as a comparison and deemed unsuccessful.
Journal: Food Chemistry - Volume 197, Part A, 15 April 2016, Pages 496–502