کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1198919 | 1493549 | 2015 | 14 صفحه PDF | دانلود رایگان |
• Recent advances towards infectious pathogens diagnostics are introduced.
• Integrated microfluidic devices for infectious disease diagnostics are summarized.
• Current challenges and future perspectives for POC diagnostics are discussed.
Rapid and timely diagnosis of infectious diseases is a critical determinant of clinical outcomes and general public health. For the detection of various pathogens, microfluidics-based platforms offer many advantages, including speed, cost, portability, high throughput, and automation. This review provides an overview of the recent advances in microfluidic technologies for point-of-care (POC) diagnostics for infectious diseases. The key aspects of such technologies for the development of a fully integrated POC platform are introduced, including sample preparation, on-chip nucleic acid analysis and immunoassay, and system integration/automation. The current challenges to practical implementation of this technology are discussed together with future perspectives.
Journal: Journal of Chromatography A - Volume 1377, 16 January 2015, Pages 13–26