Experimental comparison of chiral metal-organic framework used as stationary phase in chromatography

• An experimental comparison of a chiral MOF as CSP in GC, HPLC and CEC, respectively.
• The first example of using chiral MOF-packed column for the separation of chiral compounds in CEC.
• It is practicable that the separation of enantiomers on these chiral MOF columns.

Chiral metal-organic frameworks (MOFs) are a new class of multifunctional material, which possess diverse structures and unusual properties such as high surface area, uniform and permanent cavities, as well as good chemical and thermal stability. Their chiral functionality makes them attractive as novel enantioselective adsorbents and stationary phases in separation science. In this paper, the experimental comparison of a chiral MOF [In3O(obb)3(HCO2)(H2O)] solvent used as a stationary phase was investigated in gas chromatography (GC), high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The potential relationship between the structure and components of chiral MOFs with their chiral recognition ability and selectivity are presented.