کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1199376 1493567 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel dummy molecularly imprinted polymers for matrix solid-phase dispersion extraction of eight fluoroquinolones from fish samples
ترجمه فارسی عنوان
پلیمرهای مؤثر مولکولی نوشتار برای استخراج پراکندگی ماتریس جامد هشت فلووروکینولون از نمونه های ماهی
کلمات کلیدی
فلوروکینولون ها، پلیمرهای مونومر شده قالب ساختگی، کلاس انتخابی ماتریس پراکندگی فاز جامد
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Highly class-selective DMIPs for FQs prepared by using daidzein as a non-poisonous dummy template.
• Simultaneous determination of eight FQs from fish samples using the developed DMI-MSPD-HPLC-FLD method.
• Highly selective and sensitive method with good recovery and precision.

A series of novel dummy molecularly imprinted polymers (DMIPs) were prepared as highly class-selective sorbents for fluoroquinolones. A non-poisonous dummy template, daidzein, was used for the first time to create specific molecular recognition sites for fluoroquinolones in the synthesized polymers. The influence of porogen polarity on dummy molecular imprinting effect was studied. The DMIP prepared using dimethylsulfoxide−acetonitrile (1:1.8, v/v) as porogen achieved the highest imprinting factors (IF) for fluoroquinolones over a range of IF 13.4–84.0. This DMIP was then used for selective extraction of eight fluoroquinolones (fleroxacin, ofloxacin, norfloxacin, pefloxacin, ciprofloxacin, lomefloxacin, enrofloxacin and gatifloxacin) from fish samples based on dummy molecularly imprinted matrix solid-phase dispersion (DMI-MSPD). The extracted fluoroquinolones were subsequently analyzed by high-performance liquid chromatography (HPLC) equipped with a fluorescence detector (FLD). The developed method had acceptable recoveries (64.4−102.7%) and precision (RSDs: 1.7−8.5%, n = 5) for determination of fluoroquinolones in fish samples fortified at levels of 10 and 100 ng g−1. The limits of detection (LODs) for identification of eight fluoroquinolones ranged between 0.06 and 0.22 ng g−1. The results demonstrated great potential of the optimized method for sample preparation in routine analysis of trace fluoroquinolones in fish samples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1359, 12 September 2014, Pages 1–7
نویسندگان
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