کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1199408 1493567 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of greatly-reduced gas flows in flow-modulated comprehensive two-dimensional gas chromatography-mass spectrometry
ترجمه فارسی عنوان
استفاده از جریان گاز به میزان قابل توجهی در طیف سنج جرم کروماتوگرافی گاز جامد دو بعدی جامد جریان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• We propose a fine optimization approach in flow-modulated comprehensive 2D GC.
• The approach enables the use of MS-compatible flows (6–8 mL/min).
• 100% of the second-dimension flow is directed to the mass spectrometer.
• Sensitivity is greatly increased compared to previous findings.

The present research is specifically based on the use of greatly-reduced gas flows, in flow-modulator (FM) comprehensive two-dimensional gas chromatography systems. In particular, focus of the present research is directed to FM devices characterized by an accumulation stage, and a much briefer re-injection step. It has been widely accepted that the operation of such FM systems requires high gas flows (≥20 mL/min), to re-inject the gas-phase contents of sample (or accumulation) loops, onto the second column. On the contrary, it will be herein demonstrated that much lower gas flows (≈ 6–8 mL/min) can efficiently perform the modulation step of re-injection. The possibility of using such improved operational conditions is given simply by a fine optimization of the processes of accumulation and re-injection. The application of lower gas flows not only means that second-dimension separations are carried out under better analytical conditions, but, even more importantly, greatly reduces problems which arise when using mass spectrometry (i.e., sensitivity and instrumental pumping capacity).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1359, 12 September 2014, Pages 271–276
نویسندگان
, , , ,