کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1200479 1493483 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection
ترجمه فارسی عنوان
مخلوط آب با گرافیت اکسید گرافن / مولکولی و مشتق شده پلیمر پوشش داده شده نوار بارگیری جذب استخراج پروپرانولول از نمونه های ادرار و پس از آن با استفاده از کروماتوگرافی مایع عملکرد بالا و فرابنفش
کلمات کلیدی
اکسید گرافن / پلیمر مولکولی سازگاری آب، مخلوط کردن بار جذبی کروماتوگرافی مایع با عملکرد بالا - آشکارساز فرابنفش نمونه ی ادرار
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• A GO/MIP coating was prepared with good water compatibility and adsorption performance.
• GO/MIP coating showed high chemical stability and good selectivity for propranolol.
• GO/MIP-SBSE-HPLC-UV method exhibited good application potential in urine analysis.

Due to the high selectivity and stability, molecularly imprinted polymers (MIPs) have been successfully applied in stir bar sorptive extraction (SBSE) as a special coating to improve the selective extraction capability for target analytes. However, traditional MIPs usually suffer from incompatibility in aqueous media and low adsorption capacity, which limit the application of MIP coated stir bar in aqueous samples. To solve these problems, a water-compatible graphene oxides (GO)/MIP composite coated stir bar was prepared in this work by in situ polymerization. The prepared water-compatible GO/MIP coated stir bar presented good mechanical strength and chemical stability, and its recognition ability in aqueous samples was improved due to the polymerization of MIP in water environment, the adsorption capacity for target analytes was also increased by the addition of GO in MIP pre-polymer solution. Based on it, a method of water-compatible GO/MIP coated stir bar sorptive extraction combined with high performance liquid chromatography-ultraviolet detector (HPLV-UV) was proposed for the analysis of propranolol (PRO) in aqueous solution. The influencing factors of SBSE, such as sample pH, salt effect, stirring rate, extraction time, desorption solvent and desorption time, were optimized, and the analytical performance of the developed SBSE-HPLC-UV method was evaluated under the optimized conditions. The limit of detection (LOD) of the proposed method for PRO was about 0.37 μg L−1, and the enrichment factor (EF) was 59.7-fold (theoretical EF was 100-fold). The reproducibility was also investigated at concentrations of 5 μg L−1 and the relative standard deviation (RSD) was found to be 7.3% (n = 7). The proposed method of GO/MIP coating-SBSE-HPLC-UV was successfully applied for the assay of the interested PRO drug in urine samples, and further extended to the investigation of the excretion of the drugs by monitoring the variation of the concentration of PRO in urine within 10 h after drug-taking.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1443, 22 April 2016, Pages 1–9
نویسندگان
, , , , , ,