کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1201822 | 965045 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enantiomeric resolution of (±)-licarin A by high-performance liquid-chromatography using a chiral stationary phase
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enantiomeric resolution of (±)-licarin A by high-performance liquid-chromatography using a chiral stationary phase Enantiomeric resolution of (±)-licarin A by high-performance liquid-chromatography using a chiral stationary phase](/preview/png/1201822.png)
چکیده انگلیسی
(±)-Licarin A (1), a neolignan obtained by the oxidative coupling reaction of isoeugenol, had in this study its enantiomers resolved. A novel, quick and efficient enantiomeric resolution of 1 was directly performed by chiral high-performance liquid chromatography (HPLC-PDA) protocol (CHIRALPACK® AD column; 9:1 (v/v) n-hexane:2-propanol; 1.0 mL/min). This method provided a chromatogram profile with a well-resolved peak separation. After isolation of each enantiomer with ee > 99.9%, they were analysed in a polarimeter. Compound 2, which showed a retention time (tr) of 12.13 min, was the (+)-enantiomer and compound 3 (tr = 18.90 min) was the (−)-enantiomer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1218, Issue 39, 28 September 2011, Pages 7051–7054
Journal: Journal of Chromatography A - Volume 1218, Issue 39, 28 September 2011, Pages 7051–7054
نویسندگان
Ana Carolina Pereira, Lizandra G. Magalhães, Ana Helena Januário, Patrícia M. Pauletti, Wilson Roberto Cunha, Jairo Kenupp Bastos, Dhammika N.P. Nanayakkara, Márcio Luis A. e Silva,