کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1201968 965050 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Constructing chiral caves and efficiently separating enantiomers of glutamic acid with novel surface-imprinting technique
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Constructing chiral caves and efficiently separating enantiomers of glutamic acid with novel surface-imprinting technique
چکیده انگلیسی

Dimethylaminoethyl methacrylate (DMAEMA) was first graft-polymerized onto the surfaces of micron-sized silica gel particles in the manner of “grafting from” in a solution polymerization system, obtaining the grafted particles PDMAEMA/SiO2. Then, the molecular imprinting towards the grafted PDMAEMA was conducted with one enantiomer of glutamic acid (Glu), l-Glu, as template molecule and with 2,2′-dichlorodiethylether (DCEE) as crosslinking agent by adopting the novel surface-molecular imprinting technique established by our research group, and the single enantiomer (l-Glu) molecule-imprinted material MIP-PDMAEMA/SiO2 was obtained. With another enantiomer of glutamic acid, d-Glu, as the contrast compound, the recognition property of MIP-PDMAEMA/SiO2 for l-Glu was investigated in depth with both static and dynamic methods, and its ability to separate l-Glu and d-Glu in the racemic solution was examined. The experiment results show that the surface-imprinted material MIP-PDMAEMA/SiO2 has fine recognition selectivity and binding affinity for l-Glu, whereas its ability to combine d-Glu is poor. The selectivity coefficient of MIP-PDMAEMA/SiO2 for l-Glu with respect to d-Glu is equal to 3.30, displaying an excellent chiral separation result. It is obvious that in this study, the substance separation at the molecular configuration level has been realized successfully.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1218, Issue 32, 12 August 2011, Pages 5441–5448
نویسندگان
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