کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1202027 | 1493668 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chromatographic-nuclear magnetic resonance can provide a prediction of high-pressure liquid chromatography shape selectivity tests Chromatographic-nuclear magnetic resonance can provide a prediction of high-pressure liquid chromatography shape selectivity tests](/preview/png/1202027.png)
NMR diffusometry has been recently demonstrated as a means of investigating the mobility variations of solutes induced by chromatographic phases (under the acronym chromatographic-NMR). Particularly, a given compound has its average diffusivity reduced proportionally to its affinity towards the solid. In this work we propose the first comparison of chromatographic-NMR and tests for assessment of column performance, to investigate to what measure the novel approach could provide an assay of the outcome of a given stationary phase without the need of packing the relative column. Specifically, using bulk materials, we reproduce with very good agreement a shape selectivity test as reported in the catalog of a column producer, consisting of four probe molecules, applied to two different stationary phases.
► We analyze by NMR the changes in molecular mobility induced by chromatographic phases.
► We use this method to create the equivalent of a four PAHs shape selectivity test.
► Two RPLC column materials are analyzed.
► NMR results correlate very well with their LC correspondent.
Journal: Journal of Chromatography A - Volume 1257, 28 September 2012, Pages 204–207