کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1203973 965134 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a novel restricted access chiral stationary phase based on atom transfer radical polymerization and click chemistry for the analysis of chiral drugs in biological matrices
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Synthesis of a novel restricted access chiral stationary phase based on atom transfer radical polymerization and click chemistry for the analysis of chiral drugs in biological matrices
چکیده انگلیسی

A novel chiral restricted access material was synthesized via a combination of atom transfer radical polymerization (ATRP) and click chemistry. Poly(2-methyl-3-butyn-2-ol methacrylate) (pMBMA) was grafted onto porous silica gel by a surface-initiated ATRP in order to synthesize an inner layer for β-cyclodextrin (β-CD) immobilization. The azide-modified β-CD was bound to pMBMA by click chemistry. The results demonstrate that click chemistry provides an effective route for the immobilization of β-CD for chiral discrimination. A second ATRP reaction was then used to graft external poly(glycidyl methacrylate) (pGMA) layer onto the silica gel. The external hydrophilic layer was subsequently created by hydrolysis of the epoxy groups of the pGMA. This bi-layer grafted material exhibited both enantioseparation and protein exclusion. It can be used for the efficient separation of chiral compounds in biological samples with direct injection into an HPLC system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1218, Issue 9, 4 March 2011, Pages 1310–1313
نویسندگان
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