کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1205120 965182 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
“Click” immobilized perphenylcarbamated and permethylated cyclodextrin stationary phases for chiral high-performance liquid chromatography application
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
“Click” immobilized perphenylcarbamated and permethylated cyclodextrin stationary phases for chiral high-performance liquid chromatography application
چکیده انگلیسی

Two cyclodextrin-based chiral stationary phases have been prepared by immobilization of functionalized mono-6-azido-β-CD derivatives to alkynyl modified silica via “click” chemistry and applied to the HPLC enantioseparation of various chiral compounds. The perphenylcarbamated CD CSP (CCP-CSP) exhibited excellent chiral recognition of a wide range of analytes including racemic aryl alcohols, flavonoids, bendroflumethiazide, atropine and some β-blockers. Methanol proved to be a better organic modifier than acetonitrile for most of the analytes with the exception of bendroflumethiazide. The “click” chemistry immobilized permethylated CD CSP (CCM-CSP) afforded poor chiral recognition for most analytes, but could resolve non-aromatic ionone derivatives which were not separated on CCP-CSP. These results suggest that resolution with cyclodextrin derived CSPs depend on a complex interplay of ‘host’–‘guest’ inclusion, hydrogen bonding, π–π and hydrophobic interactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1217, Issue 31, 30 July 2010, Pages 5103–5108
نویسندگان
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