کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1205186 965185 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In situ derivatization reaction and determination of ibuprofen in water samples using headspace generation-programmed temperature vaporization-gas chromatography-mass spectrometry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
In situ derivatization reaction and determination of ibuprofen in water samples using headspace generation-programmed temperature vaporization-gas chromatography-mass spectrometry
چکیده انگلیسی

The aim of the present work is to propose a method for the determination of ibuprofen, as a typical representative of pharmaceutical compounds, in aqueous samples. To do so, an in situ derivatization reaction in aqueous medium was employed in the vial of a headspace sampler (HS), after which instrumental measurements were made with gas chromatography-mass spectrometry (GC-MS). As the injection system we propose a programmed temperature vaporizer (PTV) where, in solvent vent mode, better results can be obtained than with the conventional split and splitless injection modes. Since the derivatization reaction takes place in the HS vial, after the mixing of reagents and the sealing of the vial, the whole process takes place on-line, with no need for intermediate steps. The simplicity and speed of the method – analysis throughput: 10.5 min – together with the limit of detection obtained (0.23 μg/L), bearing in mind that no preconcentration step or later clean-up step are required, make this a good method for the analysis of ibuprofen in aqueous samples of urban waste water.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1216, Issue 39, 25 September 2009, Pages 6728–6734
نویسندگان
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