کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1205431 | 965196 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High performance liquid chromatographic evaluation of artemisinin, raw material in the synthesis of artesunate and artemether
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A barrier to the development of artemisinin derivative based combination treatment of malaria is the lack of defined specifications and purity test methods for the raw material artemisinin. An HPLC method previously published in the International Pharmacopoeia to evaluate purity of artemisinin as an active pharmaceutical ingredient is adapted for use. Excellent method precision and linearity are demonstrated along with observations of robustness. In support of the development of specifications major impurities are identified using high resolution HPLC–MS, isolation via preparative HPLC followed by NMR. The identified impurities differ from those previously claimed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1216, Issue 51, 18 December 2009, Pages 8918–8925
Journal: Journal of Chromatography A - Volume 1216, Issue 51, 18 December 2009, Pages 8918–8925
نویسندگان
Rodger W. Stringham, Kenneth G. Lynam, Peter Mrozinski, Greg Kilby, István Pelczer, Christina Kraml,