کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1206678 1493717 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting blood–brain barrier penetration of drugs by microemulsion liquid chromatography with corrected retention factor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Predicting blood–brain barrier penetration of drugs by microemulsion liquid chromatography with corrected retention factor
چکیده انگلیسی

This study attempted to optimize the compositions of microemulsion mobile phase to model the drug penetration across blood–brain barrier (BBB) by microemulsion liquid chromatography (MELC). During the study, a continuous increase of the retentions along the operation time was found for all the test drugs. A correction method using methyl paraben and propranolol as the internal standards was proposed, which improved the reliability of the retention time significantly. The corrected retention factors were then used to develop the predictive model. The optimized MELC system with microemulsion consisting of 3.3% sodium dodecyl sulfate (SDS)–6.6% butanol–1.6% heptane–88.5% phosphate buffer (pH 7.0) showed superiorities to other lipophilicity measuring systems for modeling BBB penetration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volumes 1198–1199, 11 July 2008, Pages 164–172
نویسندگان
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