کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1207525 965270 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Packing density, permeability, and separation efficiency of packed microchips at different particle-aspect ratios
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Packing density, permeability, and separation efficiency of packed microchips at different particle-aspect ratios
چکیده انگلیسی

HPLC microchips are investigated experimentally with respect to packing density, pressure drop–flow rate relation, hydraulic permeability, and separation efficiency. The prototype microchips provide minimal dead volume, on-chip UV detection, and a 75 mm long separation channel with a ca. 50 μm × 75 μm trapezoidal cross-section. A custom-built stainless-steel holder allowed to adopt optimized packing conditions. Separation channels were slurry-packed with 3, 5, and 10 μm-sized spherical, porous C8-silica particles. Differences in interparticle porosity, permeability, and plate height data are analyzed and consistently explained by different microchannel-to-particle size (particle-aspect) ratios and particle size distributions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1216, Issue 2, 9 January 2009, Pages 264–273
نویسندگان
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