کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1207582 965273 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chiral ionic liquids for enantioseparation of pharmaceutical products by capillary electrophoresis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Chiral ionic liquids for enantioseparation of pharmaceutical products by capillary electrophoresis
چکیده انگلیسی

A chiral ionic liquid (IL), S-[3-(chloro-2-hydroxypropyl)trimethylammonium] [bis((trifluoromethyl)sulfonyl)amide] (S-[CHTA]+[Tf2N]−), which can be easily and readily synthesized in a one-step process from commercially available reagents, can be successfully used both as co-electrolyte and as a chiral selector for CE. A variety of pharmaceutical products including atenolol, propranolol, warfarin, indoprofen, ketoprofen, ibuprofen and flurbiprofen, can be successfully and baseline separated with the use of this IL as electrolyte. Interestingly, while S-[CHTA]+[Tf2N]− can also serve as a chiral selector, enantioseparation cannot be successfully achieved with S-[CHTA]+[Tf2N]− as the only chiral selector. In the case of ibuprofen, a second chiral selector, namely a chiral anion (sodium cholate), is needed for the chiral separation. For furbiprofen, in addition to S-[CHTA]+[Tf2N]− and sodium cholate, a third and neutral chiral selector, 1-S-octyl-β-d-thioglucopyranoside (OTG), is also needed. Due to the fact that the chirality of this chiral IL resides on the cation (i.e., -[CHTA]+), and that needed additional chiral selector(s) are either chiral anion (i.e., cholate) or chiral neutral compound (OTG), the results obtained seem to suggest that additional chiral selector(s) are needed to provide the three-point interactions needed for chiral separations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1204, Issue 2, 19 September 2008, Pages 204–209
نویسندگان
, ,