کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1208047 | 965288 | 2008 | 4 صفحه PDF | دانلود رایگان |
Racemic vigabatrin, an anticonvulsant drug used for the treatment of epilepsy, and its analogue γ-amino acids were resolved without derivatization on liquid chromatographic chiral stationary phases (CSPs) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. Between the two CSPs which contain 3 methylene-unit or 11 methylene-unit spacer group, the latter was found to be greater than the former in the resolution of vigabatrin and its analogue γ-amino acids, the separation, α, and the resolution factor, RS, for the resolution of vigabatrin on the latter being 1.91 and 4.57, respectively. The chromatographic behaviors for the resolution of vigabatrin and its analogue γ-amino acids on the two CSPs were found to be dependent on the type and the content of organic and acidic modifiers in aqueous mobile phase.
Journal: Journal of Chromatography A - Volume 1188, Issue 2, 25 April 2008, Pages 318–321