کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1208264 1493744 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
P-BOSS: A new filtering method for treasure hunting in metabolomics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
P-BOSS: A new filtering method for treasure hunting in metabolomics
چکیده انگلیسی

Metabolomics is expected to boost data driven research. In biomarker discovery, powerful filtering methods to remove noise and outliers are essential for screening significant candidates from the huge volume of omic data. Here we propose a post-measurement peak filtering method (named P-BOSS) for CE electrospray ionization–time-of-flight MS (CE–TOFMS) data. Combining outlier detection method functions in parallel, we applied P-BOSS to the data using Escherichia coli knockout mutants of the tryptophan and purine biosynthesis pathways. As the result, P-BOSS showed remarkably superior performance, reducing 65% of all peaks, while leaving significant peaks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1159, Issues 1–2, 3 August 2007, Pages 142–148
نویسندگان
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