کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1208542 1493748 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin
چکیده انگلیسی

The affinity of indole-3-acetic acid (IAA), indole-3-propionic acid, indole-3-butyric acid and 24 of their amino acid conjugates to immobilized human serum albumin, as expressed by the retention factor k (determined by HPLC), was dependent on (1) lipophilicity, (2) chirality and (3) functional groups in the amino acid moiety; in some cases conformation plays an additional role. Two lipophilicity-related parameters afforded quantitative correlations with k: retention on a C18 reversed-phase column (experimental approach) and the distance between the hydrophilic and hydrophobic poles of the molecules (in silico approach). Most compounds examined are possible metabolic precursors of IAA, an experimental tumor therapeutic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1154, Issues 1–2, 22 June 2007, Pages 240–249
نویسندگان
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