کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1211457 | 1493762 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficacy of planar chromatography coupled to (tandem) mass spectrometry for employment in trace analysis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
HPTLC/MS by a plunger-based extraction device was shown to be an appropriate technique for quantitative planar chromatography, even in trace analysis. Reproducible extraction from silica gel phases in the lower-pg range distinguishes this technique from other approaches. Repeatability of the MS signal showed a mean RSD of 12.5% for the example of Harman, a heterocyclic aromatic amine. Analytical response within a plate and over various plates/days showed determination coefficients of 0.9915 and 0.9488, respectively. Limit of detection (LOD) by a single quadrupole was better than 40Â pg and limit of quantitation (LOQ) by a tandem mass spectrometer better than 20Â pg. LOQ/LOD obtained were of similar magnitude as reported for HPLC/MS methods, however, this order of sensitivity was shown for the first time in the field of HPTLC/electrospray ionization MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1128, Issues 1â2, 22 September 2006, Pages 244-250
Journal: Journal of Chromatography A - Volume 1128, Issues 1â2, 22 September 2006, Pages 244-250
نویسندگان
Ute Jautz, Gertrud Morlock,