کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1214368 1494155 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of methocarbamol concentration in human plasma by high performance liquid chromatography–tandem mass spectrometry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of methocarbamol concentration in human plasma by high performance liquid chromatography–tandem mass spectrometry
چکیده انگلیسی

A simple and reproducible high performance liquid chromatography–tandem mass spectrometric method was developed for methocarbamol analysis in human plasma. Methocarbamol and the internal standard (IS) were extracted by a protein precipitation method. Under isocratic separation condition the chromatographic run time was 3.0 min. The calibration curve was linear over a range of 150–12,000 ng/mL with good intraday assay and interday assay precision (CV% < 10.9%). The method was proven to be sensitive and selective for the analysis of methocarbamol in human plasma for bioequivalence study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 878, Issues 9–10, 15 March 2010, Pages 831–835
نویسندگان
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