کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1215749 | 1494076 | 2014 | 8 صفحه PDF | دانلود رایگان |
• LC–MS/MS method for nine macrolide and three lincosamide antibiotics in seafood.
• Extension of a quantitative confirmatory method for analytes in bovine kidney.
• Applicable to salmon, shrimp and tilapia in range of 5.0–50.0 μg/kg.
• First report of method for gamithromycin, pirlimycin and tildipirosin in seafood.
This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography–tandem mass spectrometric method for residues of macrolide and lincosamide antibiotics, originally validated for application to bovine kidney tissues, to tissues of salmon, shrimp and tilapia. The 12 analytes include clindamycin, erythromycin A, gamithromycin, josamycin, lincomycin, neospiramycin 1, oleandomycin, pirlimycin, spiramycin 1, tildipirosin, tilmicosin and tylosin A. The limit of detection was 0.5 μg/kg. Within-laboratory precision evaluated over the analytical range of 5.0–50.0 μg/kg ranged from 4 to 17%. The accuracy of the method ranged from 80 to 112%. Recoveries ranged from 47 to 99% with all but one recovery above 60%. This is the first report of a quantitative confirmatory method for gamithromycin, pirlimycin and tildipirosin in fish and shrimp.
Journal: Journal of Chromatography B - Volume 967, 15 September 2014, Pages 203–210