Determination of terbutaline sulfate by capillary electrophoresis with chemiluminescence detection

A novel capillary electrophoresis (CE) with chemiluminescence (CL) detection method for determination of terbutaline sulfate has been developed. This method is based on the chemiluminescence reaction of potassium ferricyanide with luminol in sodium hydroxide medium sensitized by terbutaline sulfate. With the peak height as a quantitative parameter applying optimum working conditions, terbutaline sulfate is determined over the range of 7.0 × 10−8 to 3.6 × 10−6 M with a detection limit of 3.0 × 10−8 M. The relative standard deviation (RSD) was 4.6% for 6.0 × 10−7 M terbutaline sulfate (n = 11). The proposed method has been applied to determination of terbutaline sulfate in commercial terbutaline sulfate drug and spiked in human urine with satisfactory results.