کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1219496 1494543 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postharvest storage of Carioca bean (Phaseolus vulgaris L.) did not impair inhibition of inflammation in lipopolysaccharide-induced human THP-1 macrophage-like cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Postharvest storage of Carioca bean (Phaseolus vulgaris L.) did not impair inhibition of inflammation in lipopolysaccharide-induced human THP-1 macrophage-like cells
چکیده انگلیسی


• Peptides from Carioca beans inhibited inflammation in human THP-1 macrophages.
• Short time-storage did not impair biological properties of Carioca beans.
• Hydrolysates from Carioca beans present antioxidant and anti-inflammatory activity.

Storage can affect the nutritional quality of common bean (Phaseolus vulgaris), but little is known about the postharvest effect of storage on inflammation. The aim of this work was to evaluate, in vitro, the effect of postharvest storage-time on inflammation by Carioca beans, Madreperola (MP) and Pontal (PO), stored (0, 3 and 6 months), cooked and subjected to pepsin-pancreatin simulated gastrointestinal digestion. Anti-inflammatory potential was investigated in human THP-1 macrophage-like cells. Commercial storage time did not affect protein concentration, degree of hydrolysis, hydropathicity or antioxidant capacity. All PO hydrolysates reduced tumour necrosis factor-α (TNF- α) (31% on average). MP hydrolysates decreased interleukin 1β (IL-1β) (PO 0: 0.1 mg/mL, 20.7%; PO 0 and 6: 5 mg/mL, 24.8 and 48.2%, respectively) and prostaglandin E-2 (PGE-2) (PO 0: all concentrations, 18% on average; PO 6: 0.1 mg/mL, 18.6%). Carioca beans inhibited inflammation and commercial storage time did not impair physicochemical or biological properties.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 23, May 2016, Pages 154–166
نویسندگان
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