The radiolytic studies of cefpirome sulfate in the solid state

• We identify one degradation products of cefpirome sulfate (CPS).
• We test the quality of radiosterilized CPS by UV, FT-IR, Raman, DSC, HPLC, cytotoxic and microbiologic studies.

The possibility of applying radiation sterilization to cefpirome sulfate was investigated. The lack of changes in the chemical structure of cefpirome sulfate irradiated with a dose of 25 kGy, required to attain sterility, was confirmed by UV, FT-IR, Raman, DSC and chromatographic methods. Some radical defects with concentration no more than over a several dozen ppm were created by radiation. The antibacterial activity of cefpirome sulfate for two Gram-positive and three Gram-negative strains was changed. The radiation sterilised cefpirome sulfate was not in vitro cytotoxic against fibroblast cells.

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