کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1220707 1494645 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of a quantitative approach using surface-enhanced Raman chemical imaging: First step for the determination of an impurity in a pharmaceutical model
ترجمه فارسی عنوان
توسعه یک رویکرد کمی با استفاده از اشعه ماوراء بنفش شیمیایی رامان سطح: مرحله اول برای تعیین یک ناخالص در یک مدل دارویی
کلمات کلیدی
پراکندگی رامان سطح افزایش یافته، تصویربرداری شیمیایی، مدل دارویی، پوشش کلوئیدی نقره، رویکرد کمی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• First development of a quantitative approach on a pharmaceutical model using SER-CI.
• Quantification of an impurity at concentrations around its limit of specification.
• Homogeneity study on silver colloid covering.
• Different spectral intensity normalizations tested on SER-CI data.

This publication reports, for the first time, the development of a quantitative approach using surface-enhanced Raman chemical imaging (SER-CI). A pharmaceutical model presented as tablets based on paracetamol, which is the most sold drug around the world, was used to develop this approach. 4-Aminophenol is the main impurity of paracetamol and is actively researched in pharmaceutical formulations because of its toxicity. As its concentration is generally very low (<0.1%, w/w), conventional Raman chemical imaging cannot be used.In this context, a SER-CI method was developed to quantify 4-aminophenol assessing a limit of quantification below its limit of specification of 1000 ppm. Citrate-reduced silver nanoparticles were used as SERS substrate and these nanoparticles were functionalized using 1-butanethiol. Different ways to cover the tablets surface by butanethiol-functionalized silver nanoparticles were tested and a homogeneity study of the silver nanoparticles covering was realized. This homogeneity study was performed in order to choose the best way to cover the surface of tablets by silver colloid. Afterwards, the optimization of the SER-CI approach was necessary and different spectral intensity normalizations were tested. Finally, a quantitative approach using SER-CI was developed enabling to quantify 4-aminophenol from 0.025% to 0.2% in paracetamol tablets. This quantitative approach was tested on two different series of tablets using different batches of silver nanoparticles.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 90, 5 March 2014, Pages 111–118
نویسندگان
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