Transition metal-induced degradation of a pharmaceutical compound in reversed-phase liquid chromatographic analysis

- A case study of transition metal-induced drug dimerization in HPLC analysis.
- Structures of two pseudo-dimeric degradants were elucidated.
- Degradation by transition metal-induced single electron transfer oxidation.
- Transition metal could arise from either stainless steel column frits or tubing.
- Procedures to prevent transition metal-induced drug degradation were discussed.