کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1220762 1494624 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simultaneous determination of insulin and its analogues in pharmaceutical formulations by micellar electrokinetic chromatography
ترجمه فارسی عنوان
تعیین همزمان انسولین و آنالوگ های آن در فرمولاسیون های دارویی با استفاده از کروماتوگرافی الکترو کینتیک میسل
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• A MEKC method is proposed to identify human insulin and its five analogues.
• The major degradation product of each insulin can also be separated.
• The CE method is validated for the quantification of human insulin.
• The quality control of several pharmaceutical formulations has been performed.

A simple and efficient MEKC method was developed to simultaneously determine human insulin, its five analogues, the main degradation products and the excipients usually present in injection formulations. A very fast method with a total analysis time of 3 min was then successfully validated for the analysis of human insulin and the quality control of commercial formulations was carried out.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 111, 10 July 2015, Pages 344–350
نویسندگان
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