کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1220807 1494621 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Independent comparison study of six different electronic tongues applied for pharmaceutical analysis
ترجمه فارسی عنوان
مطالعه مقایسه مستقل از شش زبان مختلف الکترونیکی که برای تجزیه و تحلیل دارویی کاربرد دارد
کلمات کلیدی
زبان الکترونیکی، مقایسه شرایط کور، ماسک طعم
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Comparison of the performance of 6 different e-tongues.
• Evaluation of taste-masked samples.
• Results were obtained under blind conditions.
• Assessment of different evaluation methods.

Electronic tongue technology based on arrays of cross-sensitive chemical sensors and chemometric data processing has attracted a lot of researchers’ attention through the last years. Several so far reported applications dealing with pharmaceutical related tasks employed different e-tongue systems to address different objectives. In this situation, it is hard to judge on the benefits and drawbacks of particular e-tongue implementations for R&D in pharmaceutics. The objective of this study was to compare the performance of six different e-tongues applied to the same set of pharmaceutical samples. For this purpose, two commercially available systems (from Insent and AlphaMOS) and four laboratory prototype systems (two potentiometric systems from Warsaw operating in flow and static modes, one potentiometric system from St. Petersburg, one voltammetric system from Barcelona) were employed. The sample set addressed in the study comprised nine different formulations based on caffeine citrate, lactose monohydrate, maltodextrine, saccharin sodium and citric acid in various combinations. To provide for the fair and unbiased comparison, samples were evaluated under blind conditions and data processing from all the systems was performed in a uniform way. Different mathematical methods were applied to judge on similarity of the e-tongues response from the samples. These were principal component analysis (PCA), RV′ matrix correlation coefficients and Tuckeŕs congruency coefficients.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 114, 10 October 2015, Pages 321–329
نویسندگان
, , , , , , , , , ,